A multimodal biomarker for concussion identification, prognosis and management.

Jacquin A, Kanakia S, Oberly D, Prichep L. 

Computer in Biology and Medicine. 2018; 102:95-103.

Traumatic brain injury (TBI) accounts for over 1.5 million emer-gency department (ED) visits annually within the United States and the vast majority of these visits are for mild injury (mTBI/concussion) [1]. In addition, the Center for Disease Control (CDC) estimates that 1.6 to 3.8 million concussions occur in sports and recreational activities annually.

Normative Data for Evaluating Mild Traumatic Brain Injury with a Handheld Neurocognitive Assessment Tool.

Vincent AS, Bailey CM, Cowan C, Cox-Fuenzalida E, Dyche J, Gorgens KA, Krawcyzk D, Young L. 

Applied Neuropsychology: Adult. 2017; 24(6):566-576.

The BrainScope Ahead 300 is designed for use by health care professionals to aid in the assessment of patients suspected of a mild traumatic brain injury. The purpose of the current study was to establish normative data for the cognitive test component of the Ahead 300 system and to evaluate the role of demographic factors on test performance. Healthy, community-dwelling adults…

Classification of Traumatic Brain Injury Severity Using Informed Data Reduction in a Series of Binary Classifier Algorithms.

Prichep LS, Jacquin A, Filipenko J, Ghosh-Dastidar S, Zabele S, Vodenčarević A, Rothman NS. 

IEEE Transactions on Neural Systems & Rehabilitation Engineering. 2012; 20(6): 806-822.

Assessment of medical disorders is often aided by ob-jective diagnostic tests which can lead to early intervention and appropriate treatment. In the case of brain dysfunction caused by head injury, there is an urgent need for quantitative evaluation methods to aid in acute triage of those subjects who have sustained traumatic brain injury (TBI).

Emergency Department Time Course for Mild Traumatic Head Injury Workup.

Michelson EA, Huff S, Loparo M, Naunheim R, Perron A, Rahm M, Smith D, Stone J, Berger A

Western Journal of Emergency, 2018; 19(4):635-640.

According to the United States (U.S.) Centers for Disease Control and Prevention, the incidence of traumatic brain injury (TBI) has increased by nearly 60% from calendar-year (CY) 2001 to CY2010 (from 521 per 100,000 persons to 824 per 100,000 persons).

Intracranial Pathology (CT+) in Emergency Room Patients With High GCS and High Standard Assessment of Concussion (SAC) Scores.

Curley KC, O'Neil BJ, Naunheim R, Wright DW. 

Journal of Head Trauma Rehabilitation. 2018; 33(3):E61-66.

Identification of concussion/mild traumatic brain injury (mTBI) remains a clinical diagnosis with no "gold standard" diagnostic tool. In addition, there are many clinical diagnostic criteria, with the World Health Organization noting 38 different suggested diagnostic criteria in a 2014 report…

Using a brain electrical activity biomarker could aid in the identification of mild Traumatic Brain Injury patients.

Naunheim R, Covassin T, Jacquin A, Hanley D, Michelson E. 

American Journal of Emergency Medicine. 2018; 36(1):142-143

The overall number of Emergency Departments (ED) visits from 2006 to 2010 reportedly increased by 3.6%, during which time visits for Traumatic Brain Injury (TBI) increased by 29.1% [1]. This sharp in-crease reflects heightened awareness about TBI, which is expected to drive…

Referrals for CT scans in mild TBI patients can be aided by the use of a brain electrical activity biomarker.

Huff JS, Naunheim R, Ghosh Dastidar S, Bazarian J, Michelson EW.  

Heightened awareness of the potential short and long-term consequences of mild traumatic brain injury (mTBI or concussion) has result-ed in an increase in Emergency Department (ED) visits for traumatic head injury, even as the volume of overall ED visits has remained stable…

Increased Prognostic Accuracy of TBI when a Brain Electrical Activity Biomarker is Added to Loss of Consciousness (LOC).

American Journal of Emergency Medicine. 2017; 35(7):949-952.

Hack D, Huff JS, Curley K, Naunheim R, Ghosh Dastidar S, Prichep LS. 

Background: Extremely high accuracy for predicting CT+ traumatic brain injury (TBI) using a quantitative EEG (QEEG) based multivariate classification algorithm was demonstrated in an independent validation trial, in Emergency Department (ED) patients, using an easy to use handheld device.

A Brain Electrical Activity (EEG) Based Biomarker of Functional Impairment in Traumatic Head Injury: A Multisite Validation Trial.

Journal of Neurotrauma. 2018; 35(1):41-47.

Hanley D, Prichep LS, Badjatia N, Bazarian J, Chiacchierini R, Curley K, Garrett J, Jones E, Naunheim R, O'Neil B, O'Neill J, Wright DW, Huff JS

The potential clinical utility of a novel quantitative electroencephalographic (EEG)-based Brain Function Index (BFI) as a measure of the presence and severity of functional brain injury was studied as part of an independent prospective validation trial.

Emergency Department Triage of Traumatic Head Injury Using Brain Electrical Activity Biomarkers

Hanley D, Prichep LS, Bazarian J, Huff JS, Naunheim R, Garrett J, Jones E, Wright DW, O'Neill J, Badjatia N, Gandhi D, Curley K, Chiacchierini R, O'Neil B, Hack D.

A brain electrical activity biomarker for identifying traumatic brain injury (TBI) in emergency department (ED) patients presenting with high Glasgow Coma Scale (GCS) after sustaining a head injury has shown promise for objective, rapid triage.