Brain Electrical Activity and TBI

  • The pathophysiology of TBI is complex and related to many different aspects of brain function, including neurometabolic, neurophysiological and structural changes in the brain.

  • An extensive scientific literature demonstrates these changes using functional and structural neuroimaging (e.g., MRI, fMRI, PET, SPECT, DTI).

  • Quantitative features of brain electrical activity (QEEG) used in the BrainScope technology have also been shown to be sensitive to these changes in brain activity, without the limitations of neuroimaging tools (e.g., availability at point of care, radiation exposure, cost-effectiveness).

  • For example, the hypometabolism reported in PET imaging in TBI is consistent with slowing of the EEG spectra seen in this population.

  • Changes in connectivity reported in TBI using Diffusion Tensor Imaging (DTI) are consistent with the phase synchrony abnormalities reported using EEG.

  • These changes are captured in the Ahead® system as a profile or pattern of brain activity distinctive of TBI (biomarker) through the application of advanced signal processing methods.